VERA PIERA LEONI

Posizione attualmente ricoperta

Titolo di studio

Specializzazione in Patologia Clinica (Università degli Studi di Sassari)

Dottorato di Ricerca in Patologia Cellulare e Molecolare (Università degli Studi di Perugia)

Laurea in Chimica e Tecnologie Farmaceutiche (Università degli Studi di Cagliari)

PUBBLICAZIONI

1.     Wekking D, Leoni VP, Lambertini M, Dessì M, Pretta A, Cadoni A, Atzori L, Scartozzi M, Solinas C. CDK4/6 inhibition in hormone receptor-positive/HER2-negative breast cancer: Biological and clinical aspects. Cytokine Growth Factor Rev. 2024 Feb;75:57-64. 

2.     Spada M, Piras C, Diana G, Leoni VP, Frau DV, Serreli G, Simbula G, Loi R, Noto A, Murgia F, Caria P, Atzori L. Glutamine Starvation Affects Cell Cycle, Oxidative Homeostasis and Metabolism in Colorectal Cancer Cells. Antioxidants (Basel). 2023 Mar 10;12(3):683. 

3.     Piras C, Pibiri M, Conte S, Ferranti G, Leoni VP, Liggi S, Spada M, Muntoni S, Caboni P, Atzori L. Metabolomics analysis of plasma samples of patients with fibromyalgia and electromagnetic sensitivity using GC-MS technique. Sci Rep. 2022 Dec 19;12(1):21923. 

4.     Piras C, Noto A, Ibba L, Deidda M, Fanos V, Muntoni S, Leoni VP, Atzori L. Contribution of Metabolomics to the Understanding of NAFLD and NASH Syndromes: A Systematic Review. Metabolites. 2021 Oct 11;11(10):694. 

5.     Serreli G, Naitza MR, Zodio S, Leoni VP, Spada M, Melis MP, Boronat A, Deiana M. Ferulic Acid Metabolites Attenuate LPS-Induced Inflammatory Response in Enterocyte-like Cells. Nutrients. 2021 Sep 10;13(9):3152. 

6.     Tronci L, Serreli G, Piras C, Frau DV, Dettori T, Deiana M, Murgia F, Santoru ML, Spada M, Leoni VP, Griffin JL, Vanni R, Atzori L, Caria P. Vitamin C Cytotoxicity and Its Effects in Redox Homeostasis and Energetic Metabolism in Papillary Thyroid Carcinoma Cell Lines. Antioxidants (Basel). 2021 May 20;10(5):809. 

7.     Santoru ML, Piras C, Murgia F, Leoni VP, Spada M, Murgia A, Liggi S, Lai MA, Usai P, Caboni P, Manzin A, Atzori L. Metabolic Alteration in Plasma and Biopsies From Patients With IBD. Inflamm Bowel Dis. 2021 Jul 27;27(8):1335-1345. 

8.     Piras, C.; Pibiri, M.; Leoni, V.P.; Cabras, F.; Restivo, A.; Griffin, J.L.; Fanos, V.; Mussap, M.; Zorcolo, L.; Atzori, L. Urinary 1H-NMR Metabolic Signature in Subjects Undergoing Colonoscopy for Colon Cancer Diagnosis. Appl. Sci. 2020, 10, 5401. 

9.     Piras C, Conte S, Pibiri M, Rao G, Muntoni S, Leoni VP, Finco G, Atzori L. Metabolomics and psychological features in fibromyalgia and electromagnetic sensitivity. Sci Rep. 2020 Nov 24;10(1):20418. 

10.  Piras C, Pibiri M, Leoni VP, Balsamo A, Tronci L, Arisci N, Mariotti S, Atzori L. Analysis of metabolomics profile in hypothyroid patients before and after thyroid hormone replacement. J Endocrinol Invest. 2020 Oct 6. 

11.  Santoru ML, Piras C, Murgia F, Spada M, Tronci L, Leoni VP, Serreli G, Deiana M, Atzori L Modulatory Effect of Nicotinic Acid on the Metabolism of Caco-2 Cells Exposed to IL-1β and LPS. Metabolites. 2020;10(5): E204. 

12.  Monica Pibiri, Pia Sulas, Tania Camboni, Vera Piera Leoni, and Gabriella Simbula. α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells. Sci Rep. 2020;10(1):7139. 

13.  Migliore C, Morando E, Ghiso E, Anastasi S, Leoni VP, Apicella M, Cora' D, Sapino A, Pietrantonio F, De Braud F, Columbano A, Segatto O, Giordano S. miR-205 mediates adaptive resistance to MET inhibition via ERRFI1 targeting and raised EGFR signaling. EMBO Mol Med, 10(9), 01 Sep 2018 

14.  Pibiri M, Leoni VP, Atzori L. Heme oxygenase-1 inhibitor tin-protoporphyrin improves liver regeneration after partial hepatectomy. Life Sci, 204:9-14, 05 May 2018 

15.  Fadda A, Gentilini D, Moi L, Barault L, Leoni VP, Sulas P, Zorcolo L, Restivo A, Cabras F, Fortunato F, Zavattari C, Varesco L, Gismondi V, De Miglio MR, Scanu AM, Colombi F, Lombardi P, Sarotto I, Loi E, [...] Zavattari P. Colorectal cancer early methylation alterations affect the crosstalk between cell and surrounding environment, tracing a biomarker signature specific for this tumor. Int J Cancer, 143(4):907-920, 06 Apr 2018 

16.  Szydlowska M, Pibiri M, Perra A, Puliga E, Mattu S, Ledda-Columbano GM, Columbano C, Leoni  VP.The thyromimetic KB2115 (Eprotirome) induces rat hepatocyte proliferation. Gene Expression, The journal of basic liver disease, 2017 Apr 13. 

17.  Pibiri M, Sulas P, Leoni VP, Perra A, Kowalik MA, Cordella A, Saggese P, Nassa G, Ravo M. Global gene expression profile of normal and regenerating liver in young and old mice. Age (Dordr). 2015 Jun;37(3):9796 

18.  Frau C, Loi R, Petrelli A, Perra A, Menegon S, Kowalik MA, Pinna S, Leoni VP, Fornari F, Gramantieri L, Ledda-Columbano GM, Giordano S, Columbano A. Local hypothyroidism favors the progression of preneoplastic lesions to hepatocellular carcinoma in rats. Hepatology. 2015 Jan;61(1):249-59. 

19.  Zhang YQ, Pilyugin M, Kuester D, Leoni VP, Li L, Casula G, Zorcolo L, Schneider-Stock R, Atzori L, Irminger-Finger I. Expression of oncogenic BARD1 isoforms affects colon cancer progression and correlates with clinical outcome. Br J Cancer. 2012 Aug 7;107(4):675-83. 

20.  Migliore C, Martin V, Leoni VP, Restivo A, Atzori L, Petrelli A, Isella C, Zorcolo L, Sarotto I, Casula G, Comoglio PM, Columbano A, Giordano S. MiR-1 downregulation cooperates with MACC1 in promoting MET overexpression in human colon cancer. Clin Cancer Res. 2012 Feb 1;18(3):737-47. 

21.  Zhang YQ, Bianco A, Malkinson AM, Leoni VP, Frau G, De Rosa N, André PA, Versace R, Boulvain M, Laurent GJ, Atzori L, Irminger-Finger I. BARD1: an independent predictor of survival in non-small cell lung cancer. Int J Cancer. 2012 Jul 1;131(1):83-94. 

22.  Leoni VP, Ledda-Columbano GM, Pibiri M, Saliba C, Perra A, Kowalik MA, Grober  OM, Ravo M, Weisz A, Locker J, Ghiso E, Giordano S, Columbano A. Expression of c-jun is not mandatory for mouse hepatocyte proliferation induced by two nuclear receptor ligands: TCPOBOP and T3. J Hepatol. 2011 Nov;55(5):1069-78. 

23.  Galvan A, Falvella FS, Spinola M, Frullanti E, Leoni VP, Noci S, Alonso MR, Zolin A, Spada E, Milani S, Pastorino U, Incarbone M, Santambrogio L, Neira AG, Dragani TA. A polygenic model with common variants may predict lung adenocarcinoma risk in humans. Int J Cancer. 2008 Nov 15;123(10):2327-30. 

24.  Spinola M, Leoni VP, Galvan A, Korsching E, Conti B, Pastorino U, Ravagnani F, Columbano A, Skaug V, Haugen A, Dragani TA. Genome-wide single nucleotide polymorphism analysis of lung cancer risk detects the KLF6 gene. Cancer Letters, 2007 Jun 28; 251(2):311-6. 

25.  Spinola M, Falvella FS, Galvan A, Pignatiello C, Leoni VP, Pastorino U, Paroni R, Chen S, Skaug V, Haugen A, Dragani TA. Ethnic differences in frequencies of gene polymorphism in the MYCL1 region and modulation of lung cancer patient’s survival. Lung Cancer.2007 Mar;55(3):271-7. 

26.  Manenti G, Galbiati F, Pettinicchio A, Spinola M, Piconese S, Leoni VP,Conti B, Ravagnani F, Incarbone M, Pastorino U, Dragani TA.  A V141L polymorphism of the human LRMP gene is associated with survival of lung cancer patients. Carcinogenesis. 2006 Jul;27(7):1386-90. 

27.  Spinola M, Leoni V, Pignatiello C, Conti B, Ravagnani F, Pastorino U, Dragani TA.   Functional FGFR4 Gly388Arg polymorphism predicts prognosis in lung adenocarcinoma patients. J Clin Oncol. 2005 Oct 10;23(29):7307-11. 

28.  Spinola M, Leoni VP, Tanuma J, Pettinicchio A, Frattini M, Signoroni S, Agresti R, Giovanazzi R, Pilotti S, Bertario L, Ravagnani F, Dragani TA.   FGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer. Oncol Rep. 2005Aug;14(2):415-9. 

29.  Raimondi S, Boffetta P, Anttila S, Brockmoller J, Butkiewicz D, Cascorbi I, Clapper ML, Dragani TA, Garte S, Gsur A, Haidinger G, Hirvonen A, Ingelman-Sundberg M, Kalina I, Lan Q, Leoni VP, Marchand LL, London SJ, Neri M, Povey AC, Rannug A, Reszka E, Ryberg D, Risch A, Romkes M, Ruano-Ravina A, Schoket B, Spinola M, Sugimura H, Wu X, Taioli E.   Metabolic gene polymorphisms and lung cancer risk in non-smokers An update of the GSEC study. Mutat Res. 2005, Dec 30;592(1-2):45-57.

dicembre 2007 - oggi   Tecnico di Laboratorio, categoria D, Area Tecnico-Scientifica.  Principali attività di ricerca: analisi del profilo metabolomico di linee cellulari tumorali e identificazione delle pathways molecolari associate alla progressione neoplastica;  identificazione delle alterazioni genetiche ed epigenetiche responsabili dello sviluppo e della progressione tumorale.

marzo 2003 - gennaio 2006   Attività di ricerca svolta presso l’Istituto Nazionale per lo Studio e la Cura dei Tumori, Divisione di Oncologia sperimentale, unità operativa “Meccanismi di Ereditarietà Poligenica”, Milano

INCARICHI DIDATTICI 

AA 2017-2018 e AA 2018-2019    Incarico di Insegnamento: “Patologia Generale, Fisiopatologia e Immunologia” per il Corso di Laurea in Infermieristica, Università di Cagliari 

AA 2021-2022: Incarico di Insegnamento di “Patologia Clinica” per il Corso di Laurea in Ostetricia, Università di Cagliari

inglese

Università degli Studi di Cagliari - Curriculum Vitae